Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 45, Issue 12, Pages 2808-2820Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2013.09.016
Keywords
CD46; Complement; Th1 cells; Autoimmunity; Infection
Categories
Funding
- MRC Research Grant [G1002165]
- EU-funded Innovative Medicines Initiative BTCURE
- PCUK
- Heathside Trust
- TUF
- GSTT Charity
- TSB
- National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
- MRC Centre for Transplantation
- MRC [G1002165] Funding Source: UKRI
- Medical Research Council [MR/J006742/1, G1002165] Funding Source: researchfish
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Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4(+) T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose. (C) 2013 Elsevier Ltd. All rights reserved.
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