Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 44, Issue 5, Pages 709-713Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2012.01.023
Keywords
Brain; Matrix metalloproteinase-9; Dendritic spine morphology; Synaptic plasticity; Memory and learning processes
Categories
Funding
- ERA-NET NEURON MODDIFSYN
- Polish Ministry of Science and Higher Education [N N301 033134]
- COST Action [BM1001]
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Matrix metalloproteinase-9 (MMP-9), an extracellularly acting. Zn2+-dependent endopeptidase is a subject to complex regulation at the level of transcription, mRNA dendritic translocation, and local translation as well as protein activation, as it is released extracellularly in a latent, pro-form with the enzymatic site covered by a propeptide that has to be cleaved off to reveal the activity. In neurons, MMP-9 is present at the postsynaptic domains of excitatory synapses. Here, we review the role of MMP-9 in induction of structural dendritic spine modifications and in synaptic plasticity. In particular, we focus on local translation, activity-dependent secretion and activation of MMP-9 leading to its role in long term potentiation and regulation of remodeling of dendritic spines. (c) 2012 Elsevier Ltd. All rights reserved.
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