Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 44, Issue 11, Pages 2060-2064Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2012.08.007
Keywords
Exosomes; Intercellular communication; microRNAs; Biomarkers
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Funding
- German Federal Ministry of Education and Research Integrated Research and Treatment Center [IFBTX: 01EO0802]
- Deutsche Forschungsgemeinschaft [DFG: TH903/7-2]
- internal Hannover Biomedical Research School (HBRS) program Molecular Medicine
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Exosomes are small membrane vesicles of endosomal origin, which are secreted from a variety of cell types. During the 1980s exosomes were first described as organelles to remove cell debris and unwanted molecules. The discovery that exosomes contain proteins, messenger and microRNAs suggests a role as mediators in cell-to-cell communication. Exosomes can be transported between different cells and influence physiological pathways in the recipient cells. In the present review, we will summarize the biological function of exosomes and their involvement in physiological and pathological processes. Moreover, the potential clinical application of exosomes as biomarkers and therapeutic tools will be discussed. (C) 2012 Elsevier Ltd. All rights reserved.
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