Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 43, Issue 2, Pages 257-264Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2010.06.020
Keywords
Development; Cholangiocyte; Biliary; Differentiation; Morphogenesis
Categories
Funding
- NIDDK NIH HHS [R03 DK076583, R01 DK083355-02, R01 DK083355-01, R03 DK076583-01, R01 DK083355-03, R01 DK083355, R03 DK076583-02] Funding Source: Medline
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The mammalian biliary system, consisting of the intrahepatic and extrahepatic bile ducts, is responsible for transporting bile from the liver to the intestine. Bile duct dysfunction, as is seen in some congenital biliary diseases such as Alagille syndrome and biliary atresia, can lead to the accumulation of bile in the liver, preventing the excretion of detoxification products and ultimately leading to liver damage. Bile duct formation requires coordinated cell-cell interactions, resulting in the regulation of cell differentiation and morphogenesis. Multiple signaling molecules and transcription factors have been identified as important regulators of bile duct development. This review summarizes recent progress in the field. Insights gained from studies of the molecular mechanisms of bile duct development have the potential to reveal novel mechanisms of differentiation and morphogenesis in addition to potential targets for therapy of bile duct disorders. (C) 2010 Elsevier Ltd. All rights reserved.
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