WNT1 inducible signaling pathway protein 1 (WISP1): A novel mediator linking development and disease

WISP1 is a secreted, matricellular protein allocated to the CCN protein family. The CCN protein family consists of six, modular structured, secreted proteins. WISP1 is mainly expressed during organ development and under diseased conditions, such as fibrosis or cancer. Its expression is associated with proliferation, cytoprotection, as well as extracellular matrix production, thereby representing a highly attractive therapeutical target for future applications. (C) 2010 Elsevier Ltd. All rights reserved.