Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 43, Issue 11, Pages 1550-1562Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2011.08.005
Keywords
Notch; DSL; Endocytosis; Notch dissociation; Notch inhibition; TSP2; LRP1; CCN3; MAGP; Dlk; DNER; Contactin; Periostin; EGFL7
Categories
Funding
- NIH [NS052681, NS054724, NS062816]
- Veterans Administration [5I01BX000375]
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Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of non-canonical extracellular factors has also been shown to modulate Notch signaling, conferring newly appreciated complexity to this evolutionarily conserved signal transduction system. Here, I review current concepts in Notch signaling, with a focus on work from the last decade elucidating novel extracellular proteins that up- or down-regulate signal potency. Published by Elsevier Ltd.
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