Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 42, Issue 6, Pages 789-791Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2010.01.003
Keywords
Innate immunity; NOD-like receptors; Host-pathogen interaction; Inflammasome
Categories
Funding
- National Institute of Health [R01HL094586, R21AI083871]
- American Lung Association
- The Egyptian cultural and educational bureau
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Nlrc4 is a member of the Nod-like receptors (NLRs), a family of cytosolic receptors involved in sensing bacterial molecules. NLRs are a group of proteins containing spans of leucine-rich repeats that senses bacterial factors within the eukaryotic cytosol. The recognition of bacterial factors provokes the formation of the inflammasome complex which includes specific NLRs The inflammasome is responsible for caspase-1 activation which leads to the cleavage and maturation of inflammatory cytokines such as IL-1 beta and IL-18. Nlrc4 was considered to be a devoted flagellin sensor in eukaryotic cells However, studies using a variety of pathogens such as Salmonella, Legionella, Shigella and Pseudomonas at high bacterial burdens revealed that Nlrc4 can mediate caspase-1 activation independent of bacterial flagellin On the other hand, new reports showed that Nlrc4 can restrict bacterial infection independently of caspase-1 Therefore. Nlrc4 maybe involved in sensing more than one bacterial molecule and may participate in several immune complexes. Published by Elsevier Ltd.
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