Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 42, Issue 6, Pages 805-808Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2010.01.023
Keywords
PMCA; PDZ; Scaffold; Calcium
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Since its first characterization in the erythrocyte membrane the plasma membrane Ca2+-ATPase has been well-defined as a ubiquitous mechanism for the efflux of Ca2+ from eukaryotic cells With 4 isoforms and potentially 30 splice variants, defining the absolute physiological role of plasma membrane Ca2+-ATPase has been difficult and very limited due to the lack of effective blockers/antibodies and difficulties in measuring the activity of individual isoforms This review highlights recent developments showing that specific plasma membrane Ca2+-ATPase isoforms are subject to dynamic regulation by PSD-95/Dlg/Zo-1 scaffold proteins. Such interactions support a new paradigm, that by serving as key players in multifunctional protein complexes, transporters can regulate other signalling processes independent of their primary ion pumping function (C) 2010 Elsevier Ltd All rights reserved.
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