Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 41, Issue 4, Pages 711-716Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2008.09.020
Keywords
Cerebral malaria; Heme oxygenase-1; Carbon monoxide; Methemoglobin; Free heme
Categories
Funding
- Fundacao para a Ciencia e Tecnologia, Portugal [BPD/26633/2006, BPD/31598/2006, PTDC/SAU-MII/64125/2006]
- EMBO Young Investigator Program
- Fundação para a Ciência e a Tecnologia [PTDC/SAU-MII/64125/2006] Funding Source: FCT
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Malaria causes more than 1 million deaths every year with cerebral malaria (CM) being a major cause of death in Sub-Saharan African children. The nature of the malaria-associated pathogenesis is complex and multi-factorial. A unified hypothesis involving sequestration of infected red blood cells, systemic host inflammatory response and hemostasis dysfunction has been proposed to explain the genesis of CM. In this review, we discuss the role of hemolysis, methemoglobin and free heme in CM, brought to light by our recent studies in mice as well as by other studies in humans. (C) 2008 Elsevier Ltd. All rights reserved.
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