The role of poly(ADP-ribosyl)ation in epigenetic events

Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone modifications, remodeling Of nucleosomes and higher order chromatin modifications. in the framework of chromatin remodeling activities, the poly(ADP-ribosyl)ation of nuclear proteins catalyzed by PARK particularly PARP-1 and PARP-2, plays a fundamental role and as such have the potential to orchestrate various chromatin-based biological tasks including transcription, DNA repair and differentiation. In this review, we propose a short overview of the more recent experimental data that shed light on the role of poly(ADP-ribosyl)ation in the translation of the histone code. We will essentially focus on the different mechanisms by which PARP activity regulates the global chromatin environment and how this affects cellular Pathways. (C) 2008 Elsevier Ltd. All rights reserved.