Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 41, Issue 3, Pages 455-459Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2008.08.002
Keywords
Osteoporosis; Leptin; Sympathetic nervous system; Neuromedin U
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Funding
- JSPS (the Japan Society for the Promotion of Science)
- Uehara Memorial Foundation
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Osteoporosis is caused by a failure of bone homeostasis, but the precise molecular mechanisms controlling bone homeostasis are largely unknown. Increasing evidence that neurons and neurotransmitters are intimately involved in bone remodelling has shed light on a novel regulatory mechanism for bone homeostasis, Namely, like all other homeostatic functions, bone remodelling is under the control of the hypothalamus, and osteoporosis is considered to be a neuroskeletal disease. (C) 2008 Elsevier Ltd. All rights reserved.
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