Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 41, Issue 10, Pages 1817-1827Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2009.04.010
Keywords
ER: endoplasmic reticulum; Mitochondria; MAM: mitochondria associated membranes; Calcium; ER stress; Apoptosis
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Funding
- Italian Association for Cancer Research (AIRC), Telethon
- University of Ferrara
- Italian University Ministry
- PRRIITT program of the Emilia Romagna Region
- Italian Space Agency (ASI)
- NIH [1P01AG125532-01A1]
- Italian Multiple Sclerosis Foundation (FISM)
- United Mitochondrial Disease Foundation (UMDF)
- NATIONAL INSTITUTE ON AGING [P01AG025532] Funding Source: NIH RePORTER
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Mitochondrial and endoplasmic reticulum (ER) networks are fundamental for the maintenance of cellular homeostasis and for determination of cell fate under stress conditions. Recent structural and functional studies revealed the interaction of these networks. These zones of close contact between ER and mitochondria called MAM (mitochondria associated membranes) support communication between the two organelles including bioenergetics and cell survival. The existence of macromolecular complexes in these contact sites has also been revealed. In this contribution, we will review: (i) the ER and mitochondria structure and their dynamics, (ii) the basic principles of ER mitochondrial Ca2+ transport, (iii) the physiological/pathological role of this cross-talk. (C) 2009 Elsevier Ltd. All rights reserved.
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