Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 41, Issue 10, Pages 2025-2035Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2009.02.018
Keywords
Parkinsonism; Parkin; Drp1; Fission; Fusion; Oxidative stress
Categories
Funding
- National Institutes on Aging, Intramural Research Program, NIH
- NATIONAL INSTITUTE ON AGING [ZIAAG000940] Funding Source: NIH RePORTER
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Mutations in parkin, PTEN-induced kinase 1 (PINK1) and DJ-1 can all cause autosomal recessive forms of Parkinson's disease. Recent data suggest that these recessive parkinsonism-associated genes converge within a single pathogenic pathway whose dysfunction leads to the loss of substantia nigra pars compacta neurons. The major common functional effects of all three genes relate to mitochondrial and oxidative damage, with a possible additional involvement of the ubiquitin proteasome system. This review highlights the role of the mitochondrial kinase, PINK1, in protection against mitochondrial dysfunction and how this might relate to loss of substaintia nigra neurons in recessive parkinsonism. Published by Elsevier Ltd.
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