Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 40, Issue 9, Pages 1674-1678Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2008.02.001
Keywords
ubiquitin-proteasome proteolytic system; muscle wasting; apoptosis; proteolysis; PI3K; UPC3; caspase-3
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Activation of skeletal muscle proteolysis leads to wasting in many types of catabolic/chronic diseases, Protein breakdown is basically accomplished by the activation of the ubiquitin-proteasome system. Interestingly, several publications have shown that DNA fragmentation also occurs in skeletal muscle tissue during catabolism. The present review suggests that activation of apoptosis precedes protein breakdown associated with muscle wasting. In addition, the role of the different proteolytic systems and their relation with apoptosis is emphasized. Altogether, the data presented could be used for the design of new approaches for the treatment of muscle wasting diseases. (C) 2008 Elsevier Ltd. All rights reserved.
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