Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 43, Issue 6, Pages 485-496Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2014.02.009
Keywords
Intracellular infection; Nanoparticle; Drug delivery; Antibiotic; Bacteria
Funding
- European Research Council Advanced Grant TER-NANOMED [under the European Community] [249835]
- Centre national de la recherche scientifique (CNRS)
- Universit Paris- Sud (France)
- European Research Council (ERC) [249835] Funding Source: European Research Council (ERC)
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In the intracellular penetration of most of the commonly used antibiotics. Bacteria have quickly understood that their intracellular localisation allows them to be protected from the host immune system, but also from the action of antimicrobial agents. In addition, in most cases pathogens nestle in professional phagocytic cells, and can even use them as a 'Trojan horse' to induce a secondary site of infection thereby causing persistent or recurrent infections. Thus, new strategies had to be considered in order to counteract these problems. Amongst them, nanocarriers loaded with antibiotics represent a promising approach. Nowadays, it is possible to encapsulate, incorporate or even conjugate biologically active molecules into different families of nanocarriers such as liposomes or nanoparticles in order to deliver antibiotics intracellularly and hence to treat infections. This review gives an overview of the variety of nanocarriers developed to deliver antibiotics directly into infected cells. (C) 2014 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
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