Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 44, Issue 6, Pages 528-532Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2014.07.026
Keywords
MERS-CoV; MERS; Serology; Coronavirus; Antiviral treatment; Phylogeny
Funding
- Netherlands Organisation for Scientific Research (NWO) [40-00812-98-13066]
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Serological, molecular and phylogenetic analyses of a recently imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) in Greece are reported. Although MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, viraemia was last detected 2 days after initiation of triple combination therapy with pegylated interferon, ribavirin and lopinavir/ritonavir, administered from Day 13 of illness. Phylogenetic analysis of the virus showed close similarity with other human MERS-CoVs from the recent Jeddah outbreak in Saudi Arabia. Immunoglobulin G (IgG) titres peaked 3 weeks after the onset of illness, whilst IgM levels remained constantly elevated during the follow-up period (second to fifth week of illness). Serological testing confirmed by virus neutralisation assay detected an additional case that was a close contact of the patient. (C) 2014 Published by Elsevier B.V.
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