Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 44, Issue 5, Pages 431-435Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2014.07.009
Keywords
KPC-3, Klebsiella pneumoniae; Taiwan
Funding
- Taiwan Centers for Disease Control [MOHW103-CDC-C-114-134504]
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Establishment of KPC-associated genes into a new region usually requires travellers with hospital admission and their carriage into the communities. In this report, a worldwide spreading clone carrying KPC-3 was isolated from the sputum of a hospitalised patient with a serious infection who had just come from the USA and had been admitted to a New York hospital. By genetic comparison with a strain isolated from New Jersey (NJ-KPC-21), this isolate from the traveller was genetically related. The bla(KPC-3) gene was harboured on a large plasmid with a complex structure of a Tn3-based transposon, Tn4401a. The KPC-3-carrying plasmid was very similar (>99.9% identity) to the 113 637-bp bla(KPC-3)-encoding plasmid pKpQIL that originated from the 2006 epidemic carbapenem-resistant Klebsiella pneumoniae outbreak in Israel. With the first recognition of KPC-2 in 2011 and continuing spread, physicians should be aware of the coming of KPC-3 K. pneumoniae in Taiwan. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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