Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 39, Issue 6, Pages 478-485Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2012.02.007
Keywords
Quinolone resistance; gyrA mutations; Reverse antibiotic; Nybomycin; VISA; VRSA
Funding
- Ministry of Education, Culture, Sport, Science, and Technology, Japan (MEXT) [S0991013]
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By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu50. The mutants, occurring at an extremely low rate (<1 x 10(-11)/generation), were found to have their gyrA genes back-mutated and to have lost quinolone resistance. Here we describe nybomycin as the first member of a novel class of antibiotics designated 'reverse antibiotics'. (c) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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