Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 39, Issue 5, Pages 376-380Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2012.01.012
Keywords
MDR-TB; XDR-TB; TDR-TB; Thioridazine; Cure; Enhanced intracellular killing; Inhibition of efflux pumps
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT) of Portugal [EU-FSE/FEDER-PTDC/SAU-FCF/102807/2008]
Ask authors/readers for more resources
Thioridazine (TDZ) in combination with antibiotics to which extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) is initially resistant yields a cure. This is due to the fact that TDZ enhances the killing of intracellular M. tuberculosis by non-killing macrophages, inhibits the genetic expression of efflux pumps of M. tuberculosis that extrude antibiotics prior to reaching their intended targets, and inhibits the activity of existing efflux pumps that contribute to the multidrug-resistant phenotype of M. tuberculosis. The combination of these effects of TDZ probably contributes to the successful recent cures of XDR-TB cases when the phenothiazine TDZ is used in combination with antibiotics to which the patient with XDR-TB was initially unresponsive. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available