Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 37, Issue 2, Pages 156-161Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2010.10.020
Keywords
Terpenoids; Alkaloids; Phenolics; Multidrug resistance; Efflux pump inhibitor; Antibacterial activities
Funding
- 'Agence universitaire de la Francophonie' (AUF)
- Universite de la Mediterranee and Service de Sante des Armees
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The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine beta-naphthylamide (PA beta N), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB-TolC (Enterobacteriaceae) and MexAB-OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products. (C) 2010 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
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