Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 36, Issue 3, Pages 280-283Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2010.05.006
Keywords
beta-Cyclodextrin; Silver nanoparticles; Antibacterial activity
Funding
- Dublin Institute of Technology (Dublin, Ireland)
- Enterprise Ireland
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Silver nanoparticles (AgNPs) were synthesised by reducing silver salts using NaBH(4) followed by capping with varying concentrations of beta-cyclodextrin (beta-CD) and were physically characterised. Antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was determined by a microtitre well method. The AgNPs were spherical under transmission electron microscopy, whilst dynamic light scattering showed average diameters of capped particles to be smaller (4-7 nm) than their uncapped equivalents (17 nm). Capped particles demonstrated superior photostability when exposed to intense ultraviolet radiation for 4 h as well as significantly (P < 0.05) higher (up to 3.5-fold) antibacterial activity. The influence of beta-CD concentration was seen to delay bacterial growth, indicating that a Trojan horse mechanism may be occurring owing to bacterial carbohydrate affinity, thereby enhancing silver ion absorption. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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