Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 33, Issue -, Pages S29-S32Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0924-8579(09)70013-5
Keywords
Clostridium difficile; Fluoroquinolones
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Clostridium difficile infection has become one of the most significant threats to hospitalised patients and represents an increasingly important issue in terms of morbidity and mortality within our institutions. The arrival of a new, more virulent strain coincided with the introduction of several new respiratory fluoroquinolones, and several studies have reported a potential link between the use of fluoroquinolones and the occurrence of C. difficile infection. After reviewing the available published data on this topic the evidence for a link seems to be suggestive but not conclusive. Infection-control issues seem to play a more important role than fluoroquinolone use. (C) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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