In vitro interactions of itraconazole and micafungin against clinically important filamentous fungi

The in vitro interactions between itraconazole and micafungin against 133 strains of filamentous fungi of clinical interest were evaluated using a checkerboard method. Overall, synergistic interactions were observed against 30% of the strains tested. In the cases of Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Fonsecaea spp. and Sporothrix schenckii, synergistic interactions were observed against >= 50% of the strains tested. For the rest of the fungi the interaction was indifferent; antagonism was not observed in any case. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.