Journal
INTERNATIONAL JOURNAL OF ANDROLOGY
Volume 34, Issue 4, Pages E86-E97Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2605.2011.01162.x
Keywords
epidemiology; gene polymorphism; genome studies; testicular neoplasms; testis
Categories
Funding
- Medical Research Council [G0700491] Funding Source: Medline
- MRC [G0700491] Funding Source: UKRI
- Medical Research Council [G0700491] Funding Source: researchfish
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Testicular germ-cell tumour (TGCT) is the most common cancer in young men, and genetic epidemiological studies suggest that the disease has a strong genetic basis. Until 2009, very little of this genetic component had been explained. Genome-wide association studies have since identified eight SNPs at six loci which together account for approximately 15% of the genetic risk of TGCT and offer novel biological insights into testicular germ-cell oncogenesis. In this review, we summarize the genetic epidemiology of TGCT, detail the contribution genome-wide association studies have made to our understanding of the genetic basis of TGCT and reflect on how future technological advances may assist in revealing the remaining genetic factors underlying TGCT susceptibility.
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