Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 25, Issue 2, Pages 225-234Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-015-1476-8
Keywords
2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole; Antiglycation activity; Rutin; Diabetic
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Funding
- Research Management Institute of UiTM under Dana Kecemerlangan Grant Scheme [600-RMI/DANA5/3 RIF (143/2012)]
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In the search of potent antidiabetic drug, we synthesized 1-25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1-25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1-6 and 8 showed potent activity ranging from 160.2 to 290.17 A mu M better than standard drug rutin (IC50 = 295.09 +/- A 1.04 A mu M). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds.
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