Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 42, Issue 6, Pages 575-582Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2012.03.006
Keywords
Malaria; Erythrocyte; Plasmodium; Invasion; Functional analysis; Lentivirus; Genetics; Polymorphism
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Funding
- Centers for Disease Control and Prevention, USA [R36 CK000119-01]
- Burroughs Welcome Fund New Investigator in the Pathogenesis of Infectious Diseases, USA
- National Institutes of Health, USA [R01AI057919, R01AI091787]
- Bill & Melinda Gates Foundation Grand Challenges Explorations Grant
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The Plasmodium falciparum parasite is an obligate intracellular pathogen whose invasion and remodelling of the human erythrocyte results in the clinical manifestations of malarial disease. The functional analysis of erythrocyte determinants of invasion and growth is a relatively unexplored frontier in malaria research, encompassing studies of natural variation of the erythrocyte, as well as genomic, biochemical and chemical biological and transgenic approaches. These studies have allowed the functional analysis of the erythrocyte in vitro, resulting in the discovery of critical erythrocyte determinants of Plasmodium infection. Here, we will focus on the varied approaches used for the study of the erythrocyte in Plasmodium infection, with a particular emphasis on erythrocyte invasion. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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