Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 41, Issue 6, Pages 591-594Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2011.02.001
Keywords
Triatoma infestans; Impregnated net; Sentinel guinea pig; Saliva; Antibody response
Categories
Funding
- NIH [5K01 AI079162-03, NIH 3K01AI079162-02S1, 3K01AI079162-03S1, NIH P50 AI074285-04]
- UNICEF/UNDP/World Bank/WHO
- Grant Agency of the Czech Republic [P302/11/P798]
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Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequena, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease. (C) 2011 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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