Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 40, Issue 6, Pages 635-640Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2010.02.008
Keywords
Toxoplasma gondii; Non-archetypal; Genotype; Australia; Wildlife; Marsupials
Categories
Funding
- Australian Research Council
- Department of Environment and Conservation in Western Australia
- Intramural Research Program of the National Institutes of Health (NIH)
- National Institute of Allergy and Infectious Diseases (NIAID)
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Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (81, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at 81, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia's isolation may have favoured the persistence of non-archetypal ancestral genotypes. Published by Elsevier Ltd. on behalf of Australian Society for Parasitology Inc.
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