Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 40, Issue 5, Pages 521-526Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2010.01.007
Keywords
Schistosoma mansoni; Abl tyrosine kinase; Gonad development; Gastrodermis; Imatinib
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Funding
- Deutsche Forschungsgemeinschaft DFG [GR 1549/8-1, GR 1549/5-1]
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Schistosomes cause bilharzia (schistosomiasis), one of the most prevalent parasitic diseases for human and animals worldwide. Praziquantel (PZQ) is the only widely used drug for treatment and control of this parasitemia. Since a vaccine is not yet available, and in light of emerging resistance against PZQ, the search for alternatives has high priority. Here we present that Imatinib, a compound used in human cancer therapy (Gleevec; STI-571), significantly affected schistosome morphology and physiology in vitro. Besides its negative effect on gonad development and pairing stability, Imatinib led to pathological alterations of the gastrodermis, which finally caused the death of the parasite. (C) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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