Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 39, Issue 1, Pages 13-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2008.08.003
Keywords
Parasite; Inflammation; Immune; Intestinal; Nematode; Th2
Categories
Funding
- NIAID NIH HHS [R01 AI031678-14, R01 AI031678-12, R01 AI066188-05, R01 AI031678, R01 AI066188-04, R01 AI066188-03, R01 AI066188, R01 AI031678-13] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI031678, R01AI066188] Funding Source: NIH RePORTER
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The protective immune response that develops following infection with many tissue-dwelling intestinal nematode parasites is characterised by elevations in IL-4 and IL-13 and increased numbers of CD4+ T cells, granulocytes and macrophages. These cells accumulate at the site of infection and in many cases can mediate resistance to these large multicellular pathogens. Recent studies suggest novel potential mechanisms mediated by these immune cell populations through their differential activation and ability to stimulate production of novel effector molecules. These newly discovered protective mechanisms may provide novel strategies to develop immunotherapies and vaccines against this group of pathogens. in this review, we will examine recent studies elucidating mechanisms of host protection against three widely-used experimental murine models of tissue-dwelling intestinal nematode parasites: Heligmosomoides polygyrus, Trichuris muris and Trichinella spiralis. (C) 2008 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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