Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 38, Issue 1, Pages 43-47Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2007.08.006
Keywords
RNA interference; RNAi; nematodes; Caenorhabditis elegans
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RNA interference (RNAi) has been used extensively in model organisms such as Caenorhabditis elegans. Methods developed for RNAi in C. elegans have also been used in parasitic nematodes. However, RNAi in parasitic nematodes has been unsuccessful or has had limited. success. Studies of genes essential for RNAi in C elegans and of RNAi in Caenorhabditis spp. other than C. elegans suggest two complementary, and testable, hypotheses for the limited success of RNAi in animal parasitic nematodes. These are: (i) that the external supply of double stranded RNA (dsRNA) to parasitic nematodes is inappropriate to achieve RNAi and (ii) that parasitic nematodes are functionally defective in genes required to initiate RNAi from externally supplied dsRNA. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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