4.4 Article

Correlation of biomechanics to tissue reaction in aortic aneurysms assessed by finite elements and [18F]-fluorodeoxyglucose-PET/CT

Publisher

WILEY
DOI: 10.1002/cnm.1477

Keywords

abdominal aortic aneurysm; finite element analysis; FDG-PET; CT; inflammation; mechanotransduction; metabolic activity

Funding

  1. German Science Foundation/Deutsche Forschungsgemeinschaft (DFG) within AOBJ [GE2254/1-1, RE3146/1-1, 584483]
  2. International Graduate School of Science and Engineering (IGSSE) of the Technische Universitat Munchen, Germany [3-07]

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Mechanobiological interactions are essential for the adaption of the cardiovascular system to altered environmental and internal conditions, but are poorly understood with regard to abdominal aortic aneurysm (AAA) pathogenesis, growth and rupture. In the present study, we therefore calculated mechanical AAA quantities using nonlinear finite element methods and correlated these to [18F]-fluorodeoxyglucose (FDG)-metabolic activity in the AAA wall detected by positron emission tomography/computed tomography (PET/CT). The interplay between mechanics and FDG-metabolic activity was analyzed in terms of maximum values and the three-dimensional spatial relationship, respectively.

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