Journal
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
Volume 26, Issue 3-4, Pages 471-487Publisher
WILEY
DOI: 10.1002/cnm.1274
Keywords
lattice Boltzmann methods; Immersed Boundary method; platelet near wall excess; red blood cell membrane mechanics
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Funding
- NSF [DMS-0354259, DMS-0540779]
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An Immersed Boundary method is developed in which the fluid's motion is calculated using the lattice Boltzmann method. The method is applied to explore the experimentally observed lateral redistribution of platelets and platelet-sized particles in concentrated suspensions of red blood cells undergoing channel flow. Simulations capture red-blood-cell-induced lateral platelet motion and the consequent development of a platelet concentration profile that includes an enhanced concentration within a few microns of the channel walls. In the simulations, the near-wall-enhanced concentration develops within approximately 400 ms starting from a random distribution of red blood cells and a uniform distribution of platelet-sized particles. Copyright (C) 2009 John Wiley & Sons, Ltd.
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