Inflammatory cytokines in Paget's disease of bone

This study was undertaken to evaluate the expression of inflammatory cytokines in patients with Paget's disease of bone (PDB). Serum levels of tumoral necrosis factor-alpha, interleukin 1 beta, interleukin-6 and interleukin-17 were measured in 51 patients with PDB and in 24 controls with primary osteoarthritis. Compared to controls, patients with Paget's disease of bone presented higher levels of interleukin 6 and reduced interleukin 17, but levels of tumoral necrosis factor alpha and interleukin 1 beta did not differ significantly. We found no significant differences when patients were compared according to disease activity or current treatment. There were no correlations between cytokine levels and bone-specific alkaline phosphatase or extension of Paget's disease of bone on bone scintigraphs. In conclusion, patients with PDB present significant differences on levels of certain cytokines in comparison to primary osteoarthritis patients, but these alterations did not appear to have a clear correlation with parameters of disease activity or severity. (C) 2013 Elsevier B.V. All rights reserved.