Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 20, Issue 1, Pages 170-180Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2014.02.033
Keywords
Systemic reactions; Adjuvant; Vaccine; Immunotoxicity; Action mechanisms
Categories
Funding
- UNESP
- CAPES
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Vaccine safety is a topic of concern for the treated individual, the family, the health care personnel, and the others involved in vaccination programs as recipients or providers. Adjuvants are necessary components to warrant the efficacy of vaccines, however the overstimulation of the immune system is also associated with adverse effects. Local reactions are the most frequent manifestation of toxicity induced by adjuvanted vaccines and, with the exception of the acute phase response (APR), much less is known about the systemic reactions that follow vaccination. Their low frequency or subclinical expression meant that this matter has been neglected. In this review, various systemic reactions associated with immune stimulation will be addressed, including: APR, hypersensitivity, induction or worsening of autoimmune diseases, modification of hepatic metabolism and vascular leak syndrome (VLS), with an emphasis on the mechanism involved. Finally, the authors analyze the current focus of discussion about vaccine safety and opportunities to improve the design of new adjuvanted vaccines in the future. (C) 2014 Elsevier B.V. All rights reserved.
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