Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 16, Issue 3, Pages 382-387Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2013.01.022
Keywords
Gamma delta T cells; Regulatory T cells; Cytokines; Transcription factors
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Funding
- Medical Faculty of Kiel University
- Deutsche Forschungsgemeinschaft (DFG) through the Cluster of Excellence Inflammation-at-Interfaces
- DFG Pancreatic Cancer Consortium Kiel
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gamma delta T cells account for approximately 5% of peripheral blood T cells but are more abundant in mucosal tissue. Based on the recognized ligands and their general lack of MHC restriction, gamma delta T cells are considered as unconventional T cells that link innate and adaptive immunity. gamma delta T cells produce a diverse range of cytokines, exert cytotoxic effector function, can act as antigen-presenting cells, and display regulatory activity. Here we review the current knowledge on the regulatory functions of murine and human gamma delta T cells. Some gamma delta T cells produce inhibitory cytokines such as transforming growth factor-beta but gamma delta T cells can utilize additional regulatory mechanisms. By subverting regulatory T cells (Treg) through induction of Treg apoptosis or cytokine-dependent reversal of Treg activity, however, gamma delta T cells can also enhance effector T cell activity and thereby contribute to autoimmunity. A more precise understanding of the plasticity of regulatory gamma delta T cells is required to specifically identify strategies for intentional modulation of their beneficial or detrimental regulatory activity. (C) 2013 Elsevier B.V. All rights reserved.
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