Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 16, Issue 2, Pages 125-130Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2013.03.006
Keywords
Baicalin; S. aureus mastitis; Anti-inflammation; Nuclear factor-kappaB (NF-kappa B); p38
Categories
Funding
- National Natural Science Foundation of China [30972225, 30771596, 31130053]
- Research Fund for the Doctoral Program of Higher Education of China [20110061130010]
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Mastitis is an inflammatory disease caused by microbial infection. Staphylococcus aureus is the major etiological microorganism responsible for both clinical and subclinical mastitis in dairy cows. A mouse model of S. aureus mastitis is available. Baicalin is isolated from Scutellaria and is known to have anti-inflammatory properties. This study was designed to evaluate the effects of baicalin in S. aureus mastitis. In the present study, the mouse model was infected with S. aureus to cause mammary gland inflammation. Baicalin treatment was administered from 6 h until 24 h after infection. Baicalin significantly attenuated inflammatory cell infiltration and decreased levels of TNF-alpha, IL-beta, and IL-6. Further studies revealed that baicalin downregulated phosphorylation of NF-kappa B and p38 in the mammary gland with S. aureus mastitis. Our results demonstrated that baicalin reduced the expression of the proinflammatory cytokines TNF-alpha, IL-beta, and IL-6 by inhibiting NF-kappa B and p38 phosphorylation and mRNA expression. (c) 2013 Elsevier B.V. All rights reserved.
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