Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 14, Issue 4, Pages 384-391Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2012.08.005
Keywords
Atopic dermatitis; 2,4-dinitrofluorobenzene (DNFB); NC/Nga; Omega-3; Resolvin E1
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Funding
- Kyung Hee University Research Fund [KHU-20110891]
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Atopic dermatitis (AD) is a common inflammatory skin disease for which few effective treatments are available. Resolvin E1 (RvE1; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is an endogenous lipid mediator derived from omega-3 fatty eicosapentaenoic acid, which is a potent inhibitor of inflammation. AD-like skin lesion was induced by repetitive skin contact with DNFB in NC/Nga mice and the effects of RvE1 were evaluated on the basis of histopathological findings of skin, ear swelling and cytokine production of CD4(+) T cells. Intraperitoneal injection of RvE1 for one week after DNFB challenge significantly lowered ear swelling and improved back skin lesions. In addition, RvE1 significantly suppressed production of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) by activated CD4(+) T cells and serum IgE level. Furthermore, RvE1 reduced DNFB-induced infiltration of eosinophils, mast cells, CD4(+) T cells, and CD8(+) T cells in skin lesions. Therefore, RvE1 may suppress the development of AD-like skin lesions in DNFB-treated NC/Nga mice by reducing IL-4 and IFN-gamma of activated CD4(+) T cells and serum IgE levels and infiltration of immune cells to skin lesion. (c) 2012 Elsevier B.V. All rights reserved.
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