Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 13, Issue 2, Pages 215-218Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2012.04.003
Keywords
Psoriasis; Monocyte; Dendritic cell; Interferon-alpha; Toll-like receptors; T lymphocytes
Categories
Funding
- [TAMOP-4.2.2-08/1-2008-0001]
- [TAMOP-4.2.1/B-09/1KONV-2010-0005]
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Psoriasis is a common chronic inflammatory skin disorder with serious clinical, psychosocial, and economic consequences. There is much evidence that different dendritic cell (DC) subsets, various proinflammatory cytokines and Toll-like receptors (TLRs) have a central role in the pathogenesis of the disease. One of the early events in psoriatic inflammation is the secretion of interferon (IFN)-alpha by activated plasmacytoid DCs, a special DC subset present in symptomless psoriatic skin. Secreted IFN-alpha along with other proinflammatory cytokines can lead to monocyte-derived DC (moDC) development, which might contribute to T-helper (Th)1 and Th17 lymphocyte differentiation/activation and to keratinocyte proliferation. Recently it was proven that interleukin (IL)-12 and IL-23 play a critical role in this process. Additionally in psoriatic lesions, Th1 and Th17 lympocytes can interact with monocytes and instruct these cells to differentiate into Th1- and Th17-promoting moDCs, further governing the formation and function of specialized moDC subsets. The concept we present here focuses on the initial and central role of IFN-alpha, on the importance of other proinflammatory cytokines, on TLR stimulation and on the effect of T lymphocytes in priming moDCs, which may play an important role in initiating and maintaining psoriasis. (C) 2012 Elsevier B.V. All rights reserved.
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