Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 11, Issue 3, Pages 319-322Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2010.10.004
Keywords
Th17; IL-6; TGF-beta
Categories
Funding
- National Institute of Biomedical Innovation
- Chugai-Roche Pharmaceutical Co. Ltd., Tokyo, Japan
Ask authors/readers for more resources
Naive T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various autoimmune diseases. Although several cytokines participate in Th17 cell development, IL-6 and TGF-beta are key factors for the generation of Th17 cells from naive T cells. On the other hand, IL-6 inhibits TGF-beta-induced regulatory T (Treg) cells, which suppress adaptive T cell responses and prevent autoimmunity. Recent studies suggest that it is an effective approach in the treatment of various autoimmune and inflammatory diseases to normalize the balance between Treg and Th17 cell development. Here, we review the discovery of the Th17 subset, its properties and relationship with several autoimmune diseases. Crown Copyright (c) 2010 Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available