Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 11, Issue 11, Pages 1680-1684Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2011.05.026
Keywords
Restraint stress; Immunomodulation; Free radicals; Antioxidants
Categories
Funding
- Council for Scientific and Industrial Research (CSIR)
Ask authors/readers for more resources
The present study was designed to evaluate the role of free radicals in restraint stress (RS)-induced modulation of immune responses in rats. RS significantly suppressed both humoral and cell-mediated immune responses as evidenced by reduced (a) anti-SRBC antibody titre (b) splenic Plaque Forming Cell counts, (c) footpad thickness response, and (d) IFN-gamma and IL-4 levels. Assay for oxidative stress markers in blood showed that there was significant enhancement in plasma corticosterone and products of lipid peroxidation, viz. malondialdehyde and lowered reduced glutathione levels on exposure to RS. Further, this was associated with decreased antioxidant enzyme activity, viz. superoxide dismutase and catalase. These RS-induced changes in immunological and oxidative stress markers were markedly attenuated by pretreatment with the antioxidants, L-ascorbic acid (100 and 200 mg/kg) and alpha-tocopherol (30 and 60 mg/kg), by differential degrees. The combination of L-ascorbic acid and alpha-tocopherol was shown to have synergistic effects on reversal of these RS-induced effects. The results suggest that reactive oxygen species may be involved in stress-induced immunomodulation. (C) 2011 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available