Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 10, Issue 12, Pages 1486-1490Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2010.08.007
Keywords
Regulatory T cells; CD4(+)CD25(+) cells; FoxP3; Transplantation tolerance; Adoptive cell therapy; Antigen-specificity
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Recent studies in animal models have demonstrated that adoptive transfer of antigen-specific CD4(+)CD25(+) regulatory T cells (Tregs) can prevent or even cure autoimmune diseases, and appear to induce transplantation tolerance. Thus, adoptive cell therapy using ex vivo induced and expanded patient-specific CD4(+)CD25(+) Tregs has emerged as a promising individualized medicine for the treatment of inflammatory disease. Here we discuss our current efforts on the pursuit of regulatory T cell therapy for the induction of transplantation tolerance. (C) 2010 Elsevier B.V. All rights reserved.
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