Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 10, Issue 6, Pages 648-654Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2010.03.003
Keywords
Cumaside; Cucumariosides; Sea cucumbers; Antitumor activity; Immunomodulatory activity
Categories
Funding
- Russian Academy of Science Basic Researches for Medicine
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Anew immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity against sea urchin embryos and Ehrlich carcinoma cells than the corresponding glycosides. Nevertheless Cumaside has an antitumor activity against different forms of experimental mouse Ehrlich carcinoma in vivo both independently and in combination with cytostatics. The highest effect occurs at a treatment once a day for 7 days before the tumor inoculation followed by Cumaside treatment once a day for 7 days. Prophylactic treatment with Cumaside and subsequent therapeutic application of 5-fluorouracil suppressed the tumor growth by 43%. (C) 2010 Elsevier B.V. All rights reserved.
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