Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 9, Issue 4, Pages 418-424Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2009.01.005
Keywords
Asthma; Resveratrol; Airway hyperresponsiveness; Eosinophilia; Cytokine
Categories
Funding
- Ministry of Education, Science and Technology [PDM0500839, KGM2110812]
- Republic of Korea
- Ministry of Education, Science & Technology (MoST), Republic of Korea [KGM2110812] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Asthma is an inflammatory disease of the airways, and the current focus in managing asthma is the control of inflammation. Resveratrol (3,4,5-trihydroxystilbene) is a polyphenolic stilberre found in the skins of red fruits, including grapes, that may be responsible for some of the health benefits ascribed to Consumption of red wine. We investigated the suppressive effects of resveratrol oil asthmatic parameters Such as cytokine release, eosinophilia, airway hyperresponsiveness, and mucus hypersecretion, in an OVA-induced allergic mouse model of asthma. Resveratrol significantly inhibited increases in T-helper-2-type cytokines such as IL-4 and IL-5 in plasma and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion, in the asthmatic mouse model. The efficacy of resveratrol was similar to that of dexamethasone, a glucocorticoid used as a positive control. These results suggest that resveratrol may have applications in the treatment of bronchial asthma. (C) 2009 Elsevier B.V. All rights reserved.
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