Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 8, Issue 2, Pages 135-142Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2007.08.003
Keywords
kinin; bradykinin; pathologies; diseases; inflammation; cancer; tumor; cardiovascular; renal; central nervous system
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The general description of kinins refers to these peptides as molecules involved in vascular tone regulation and inflammation. Nevertheless, in the last years a series of, evidences has shown that local hormonal systems, such as the kallikrein-kinin system, may be differently regulated and are of pivotal importance to pathophysiological control. The combined interpretations of many recent studies allow us to conclude that the kallikrein-kinin system plays broader and richer roles than those classically described until recently. In this review, we report findings concerning the participation of the kallikrein-kinin system in inflammation, cancer, and in pathologies related to cardiovascular, renal and central nervous systems. (c) 2007 Elsevier B.V. All rights reserved.
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