Journal
INTERNATIONAL ENDODONTIC JOURNAL
Volume 43, Issue 10, Pages 843-848Publisher
WILEY
DOI: 10.1111/j.1365-2591.2010.01747.x
Keywords
cytotoxicity; genotoxicity; mineral trioxide aggregate; Portland cement
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Funding
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [07/01228-4]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [561357/2008-0]
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P>Aims To evaluate whether white mineral trioxide aggregate (MTA) or white Portland cement with 15% bismuth oxide were able to induce genetic damage and cellular death ex vivo. Methodology Aliquots of 1 x 104 murine fibroblasts were incubated at 37 degrees C for 3 h with MTA (white) or white Portland cement with 15% bismuth oxide, at final concentrations ranging from 10 to 1000 mu g mL-1 individually. Data of three independent repeats from the comet assay and the trypan blue exclusion test were assessed by the one-way anova followed by Tukey's test. Results Mineral trioxide aggregate or Portland cement containing bismuth oxide did not produce genotoxic effects with respect to the single-cell gel (comet) assay data for all concentrations evaluated. Furthermore, no cytotoxicity was observed for MTA or Portland cement. Conclusion White MTA or white Portland cement containing 15% bismuth oxide were not genotoxic and cytotoxic.
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