Journal
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Volume 25, Issue 4, Pages 228-231Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YIC.0b013e328338bcf4
Keywords
antidepressant treatment; major depressive disorder; phenotype; serotonin receptor; single nucleotide polymorphism; treatment resistant depression
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Funding
- Group for the Study of Resistant Depression (GSRD)
- Lundbeck A/S
- Belgian National Fund for Scientific Research (FNSR) [3.4530.07]
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The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the -1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result. Int Clin Psychopharmacol 25: 228-231 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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