Journal
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
Volume 141, Issue -, Pages 79-86Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ibiod.2018.04.004
Keywords
Magnesium oxide; Nanoparticles; Paper heritage; Antimicrobial activity; Oxidative stress
Funding
- Fundacion General CSIC
- Fondo Social Europeo-Gobierno de Aragon
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Magnesium oxide nanoparticles (MgO NPs) have attracted considerable interest as antimicrobial agents in a wide variety of applications. We report a simple synthetic route towards MgO NPs (average diameter 10 nm) possessing potent antibacterial activity against both Gram-negative and Gram-positive bacteria. Detailed electron microscopy studies show how these particles induce oxidative stress, cell membrane leakage and cell death in bacteria at low NP concentrations, but remain non-toxic to eukaryotic cells. Applying a homogeneous dispersion of these nanoparticles on 18th century paper proved to be a highly effective means of preventing bacterial colonisation without altering the appearance of the paper samples, thus opening the doors to the use of these colourless, low-cost, and scalable nanoparticles for preventing biodeterioration in a range of paper-based objects and surfaces.
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