Journal
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Volume 159, Issue 2, Pages 179-182Publisher
KARGER
DOI: 10.1159/000336391
Keywords
Food allergy; Oral immunotherapy; Peanut allergy
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Funding
- NIH Clinical Translational Science Award (CTSA)
- Children's Health Research Program (CHRP) grant at Stanford
- Lucile Packard Children's Hospital Foundation
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Background: Peanut allergy is the leading cause of food-related anaphylaxis, and accidental exposures are common. Oral immunotherapy (OIT) has been posited as a potential treatment. Methods: Patients aged 3-65 years with peanut-specific IgE >= 7 kU/l and/or a positive skin prick test with a history of an allergic reaction to peanut were recruited to undergo an OIT protocol. All adverse reactions were recorded by research staff or patients in real time. Results: Twenty-four patients received 6,662 doses. Symptoms were mostly mild (84%), and only 3 severe gastrointestinal reactions required the administration of epinephrine. Abdominal pain was the most common reaction, followed by oropharyngeal and lip pruritus. Respiratory symptoms were rare. Conclusions: In this trial of OIT in adults and children, most reactions were mild. Copyright (C) 2012 S. Karger AG, Basel
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