Journal
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Volume 158, Issue -, Pages 92-95Publisher
KARGER
DOI: 10.1159/000337800
Keywords
Mast cells; Degranulation; I kappa B kinase 2
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government
- Global COE (Global Center for Education and Research in Immune System Regulation and Treatment), MEXT, Japan
- Grants-in-Aid for Scientific Research [23591458] Funding Source: KAKEN
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The I kappa B kinase (IKK) complex plays a crucial role in the activation of the transcription factor NF-kappa B by phosphorylating an inhibitory molecule I kappa B alpha. Recently, we showed that IKK2 (also called IKK beta), a catalytic subunit of the IKK complex, induces immunoglobulin E-mediated degranulation in mast cells by phosphorylating SNAP-23, the target-membrane soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor (SNARE). In addition to IKK2, a recent study has shown that ELKS, a regulatory subunit of the IKK complex, also induces the degranulation of rat basophilic leukemia cells. These findings indicate that the two subunits of the IKK complex, IKK2 and ELKS, function not only in NF-kappa B-dependent transcriptional activation but also in NF-kappa B-independent pathways. This review focuses on the functions of IKK2 and ELKS in mast cell degranulation. Copyright (C) 2012 S. Karger AG, Basel
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